· In 2006, she had four releases, the first being S. S. Rajamouli's Vikramarkudu opposite Raviteja, in which she portrayed the character Neeraja Goswami. The film went on to become very successful and got her much recognition that eventually made her very popular in Andhra Pradesh.
· The film astram a remake of the 1999 Hindi film Sarfarosh.
· The first Tamil film industry, acting in the Sundar C.-directed action flick Rendu sharing screen space with R. Madhavan.
· She made a special appearance in A. R. Murugadoss' directorial debut in Telugu, Stalin.
· Her first release in 2007 the film was Lakshyam after which she starred in Raghava Lawrence's Don opposite Nagarjuna again of which particularly the former did very well at the box office.
· She had appeared in six films in 2008.
· The Okka Magaadu was the first release, in which she played one of three female leads.
· Her subsequent releases Swagatam alongside Jagapati Babu and Bhumika Chawla and Baladur opposite Ravi Teja again, garnered poor reviews and box office returns. She next appeared in the film Souryam pairing with Gopichand again, which became a box office hit.
· In 2009, Shetty first starred in the block-buster hit Arundati. The film, a heroine-centric film, in which she essayed two roles for the first time, was a critical as well as commercial success ,Her performance, as Jejamma in particular, was highly critically acclaimed and fetched her first Nandi Award and the Filmfare Best Actress Award.
· Her next film, the action flick Billa, a remake of the 2007 Tamil namesake, itself a remake of the 1978 Hindi film Don.
· Her second Tamil feature film, Vettaikkaran, in which she was paired with lead actor Vijay and which she was also successful. another Tamil film singam super hit in tamil film industry